Methyl 3-isocyanothiophene-2-carboxylate is an organic compound. Its molecular formula is C8H5NO3S and its molecular weight is 195.19g/mol. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: Colorless to light yellow solid
-Melting point: 65-69°C
-Boiling point: 383°C
-Stability: stable at room temperature, but easy to get damp
-Solubility: Soluble in common organic solvents such as ethanol, acetone and dimethylformamide
Use:
-Methyl 3-isocyanothiophene-2-carboxylate is useful as an intermediate or reagent in organic synthesis.
Preparation Method:
The preparation of methyl 3-isocyanothiophene-2-carboxylate is generally carried out by the following steps:
1. First, thiophene-2-carboxylic acid ester reacts with imidazole under the action of carbonate to form thiophene-2-carboxylic acid imidazole salt.
2. Then, thiophene -2-carboxylic acid imidazole salt is hydrolyzed after reacting with methyl isocyanate in methyl chloride to obtain the target product methyl 3-isocyanothiophene -2-carboxylic acid ester.
Safety Information:
The specific hazard information and toxicity of -methyl 3-isocyanothiophene-2-carboxylate have not been systematically evaluated, so it is necessary to use caution and take appropriate protective measures during operation.
-This compound may cause irritation to the skin, eyes and respiratory tract and should be avoided.
-When using or storing, keep away from fire and high temperature.
-Must be operated in a well-ventilated place. For further information on safe operation, please consult the Safety Data Sheet (SDS) of the relevant chemical.